(5-bromo-3-pyridinyl)-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone

(5-bromo-3-pyridinyl)-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone, also known as **GW405833**, is a selective antagonist of the **neuronal nicotinic acetylcholine receptor (nAChR)**.

Here's why it's important for research:

**1. Understanding nAChR Function:**

* **nAChRs are crucial for a variety of physiological processes:** including learning, memory, muscle contraction, and pain perception.
* **GW405833 provides a valuable tool for studying specific nAChR subtypes:** by blocking their activity, researchers can understand their individual roles in these processes.

**2. Drug Development:**

* **GW405833 is a lead compound for the development of new drugs targeting nAChRs:** These drugs could potentially treat a range of disorders, including:
* **Alzheimer's disease:** by improving cognitive function.
* **Schizophrenia:** by modulating neuronal signaling.
* **Pain:** by reducing pain perception.
* **Nicotine addiction:** by reducing the rewarding effects of nicotine.

**3. Studying Neurobiology:**

* **GW405833 is used in animal models to study the effects of nAChR inhibition:** This research contributes to our understanding of brain function and can inform the development of new therapeutic strategies for various neurological conditions.

**4. Pharmacology Research:**

* **GW405833 is a powerful tool for pharmacologists:** It allows them to investigate the mechanisms of action of different drugs and to identify potential drug targets.

**Important Note:**

While GW405833 holds great promise for research and drug development, its use is currently limited to laboratory settings. It is not approved for clinical use in humans.

**In summary, (5-bromo-3-pyridinyl)-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone is a valuable research tool that provides insights into nAChR function, facilitates drug development, and contributes to our understanding of neurobiology.**